Design, Synthesis, and Evaluation of a New Chemotype Fluorescent Ligand for the P2Y<sub>2</sub> Receptor-Reference-Cited by-同舟云学术

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Design, Synthesis, and Evaluation of a New Chemotype Fluorescent Ligand for the P2Y₂ Receptor

Published:2024-06-12 Issue:7 Volume:15 Page:1127-1135
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Knight Rebecca¹²^ORCID,Kilpatrick Laura E.¹²^ORCID,Hill Stephen J.²³^ORCID,Stocks Michael J.¹^ORCID

Affiliation:

1. Division of Biomolecular Sciences and Medicinal Chemistry, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K.

2. Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, The Midlands NG7 2UH, U.K.

3. Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, U.K.

Funder

Medical Research Council

University of Nottingham

Wellcome Trust

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00211

Reference29 articles.

1. Update of P2Y receptor pharmacology: IUPHAR Review 27

2. International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy

3. The P2Y2 Nucleotide Receptor Interacts with αv Integrins to Activate Go and Induce Cell Migration

4. The P2Y2 nucleotide receptor requires interaction with αv integrins to access and activate G12

5. Src Homology 3 Binding Sites in the P2Y2 Nucleotide Receptor Interact with Src and Regulate Activities of Src, Proline-rich Tyrosine Kinase 2, and Growth Factor Receptors

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