Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure

Author:

Dohle Wolfgang1,Jourdan Fabrice L.2,Menchon Grégory3,Prota Andrea E.3,Foster Paul A.45,Mannion Pascoe45,Hamel Ernest6,Thomas Mark P.2,Kasprzyk Philip G.7,Ferrandis Eric8,Steinmetz Michel O.39,Leese Mathew P.2,Potter Barry V. L.12ORCID

Affiliation:

1. Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.

2. Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, U.K.

3. Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland

4. Institute of Metabolism and Systems Research, University of Birmingham, 2nd Floor IBR Tower, Birmingham B15 2TT, U.K.

5. Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, U.K.

6. Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702, United States

7. IPSEN, 27 Maple Street, Milford Massachusetts 01757, United States

8. Institut de Recherche Henri Beaufour, IPSEN, 91966 Les Ulis Cedex, France

9. University of Basel, Biozentrum, 4056 Basel, Switzerland

Funder

Ipsen

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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