3,17-Disubstituted 2-Alkylestra-1,3,5(10)-trien-3-ol Derivatives: Synthesis, In Vitro and In Vivo Anticancer Activity-Reference-Cited by-同舟云学术

3,17-Disubstituted 2-Alkylestra-1,3,5(10)-trien-3-ol Derivatives: Synthesis, In Vitro and In Vivo Anticancer Activity

Published:2007-08-15 Issue:18 Volume:50 Page:4431-4443
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bubert Christian¹,Leese Mathew P.¹,Mahon Mary F.¹,Ferrandis Eric¹,Regis-Lydi Sandra¹,Kasprzyk Philip G.¹,Newman Simon P.¹,Ho Yaik T.¹,Purohit Atul¹,Reed Michael J.¹,Potter Barry V. L.¹

Affiliation:

1. Medicinal Chemistry, Department of Pharmacy and Pharmacology & Sterix Ltd., University of Bath, Bath BA2 7AY, UK, Endocrinology and Metabolic Medicine and Sterix Ltd., Faculty of Medicine, Imperial College, St. Mary's Hospital, London W2 1NY, UK, Department of Chemistry, University of Bath, BA2 7AY, UK, IPSEN System Biology, 91966 Les Ulis, France, Experimental Oncology Research IPSEN/Biomeasure, Inc., 27 Maple Street Milford, Massachusetts 01757

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070405v

Reference54 articles.

1. Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate

2. Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiolmono- andbis-3-O-sulphamates

3. Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate

4. 2-Substituted Estradiol Bis-sulfamates, Multitargeted Antitumor Agents: Synthesis, In Vitro SAR, Protein Crystallography, and In Vivo Activity

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