2-Substituted Estradiol Bis-sulfamates, Multitargeted Antitumor Agents: Synthesis, In Vitro SAR, Protein Crystallography, and In Vivo Activity-Reference-Cited by-同舟云学术

2-Substituted Estradiol Bis-sulfamates, Multitargeted Antitumor Agents: Synthesis, In Vitro SAR, Protein Crystallography, and In Vivo Activity

Published:2006-12-01 Issue:26 Volume:49 Page:7683-7696
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Leese Mathew P.¹,Leblond Bertrand¹,Smith Andrew¹,Newman Simon P.¹,Di Fiore Anna¹,De Simone Giuseppina¹,Supuran Claudiu T.¹,Purohit Atul¹,Reed Michael J.¹,Potter Barry V. L.¹

Affiliation:

1. Medicinal Chemistry, Department of Pharmacy and Pharmacology & Sterix Ltd., University of Bath, Bath BA2 7AY, United Kingdom, Endocrinology and Metabolic Medicine and Sterix Ltd., Faculty of Medicine, Imperial College, St. Mary's Hospital, London W2 1NY, United Kingdom, Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy, and Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Florence, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060705x

Reference57 articles.

1. Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential

2. In vivo inhibition of oestrone sulphatase and dehydroepiandrosterone sulphatase by oestrone-3-O-sulphamate

3. Phase I Study of STX 64 (667 Coumate) in Breast Cancer Patients: The First Study of a Steroid Sulfatase Inhibitor

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