Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants-Reference-Cited by-同舟云学术

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Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants

Published:2017-05-15 Issue:10 Volume:60 Page:4424-4443
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kang Dongwei¹^ORCID,Fang Zengjun¹²,Huang Boshi¹,Lu Xueyi¹,Zhang Heng¹,Xu Haoran¹,Huo Zhipeng¹,Zhou Zhongxia¹,Yu Zhao¹,Meng Qing¹,Wu Gaochan¹,Ding Xiao¹,Tian Ye¹,Daelemans Dirk³,De Clercq Erik³,Pannecouque Christophe³,Zhan Peng¹^ORCID,Liu Xinyong¹

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong P.R. China

2. The Second Hospital of Shandong University, no. 247 Beiyuan Avenue, Jinan 250033, China

3. Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

Funder

Shandong Province

KU Leuven

Shandong University

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00332

Reference35 articles.

1. Turning the Tide Against HIV

2. Current status and challenges of antiretroviral research and therapy

3. Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

4. Strategies for the Design of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Lessons from the Development of Seven Representative Paradigms

5. HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug design

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1. Discovery of potent HIV-1 NNRTIs by CuAAC click-chemistry-based miniaturized synthesis, rapid screening and structure optimization;European Journal of Medicinal Chemistry;2024-11

2. Structure-based discovery of novel piperidine-biphenyl-DAPY derivatives as non-nucleoside reverse transcriptase inhibitors featuring improved potency, safety, and selectivity: From piperazine-biphenyl-DAPYs to piperidine-biphenyl-DAPYs;European Journal of Medicinal Chemistry;2024-10

3. Deciphering the enigmas of non‐nucleoside reverse transcriptase inhibitors (NNRTIs): A medicinal chemistry expedition towards combating HIV drug resistance;Medicinal Research Reviews;2024-08-26

4. Design and optimization of piperidine-substituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles;Acta Pharmaceutica Sinica B;2024-07

5. Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibitors featuring improved anti-resistance, selectivity, and solubility;Bioorganic Chemistry;2024-06

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