Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures-Reference-Cited by-同舟云学术

Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures

Published:2018-02-18 Issue:1 Volume:62 Page:207-222
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Christopher John A.¹^ORCID,Orgován Zoltán²,Congreve Miles¹,Doré Andrew S.¹,Errey James C.¹,Marshall Fiona H.¹,Mason Jonathan S.¹,Okrasa Krzysztof¹,Rucktooa Prakash¹,Serrano-Vega Maria J.¹,Ferenczy György G.²,Keserű György M.²

Affiliation:

1. Heptares Therapeutics Ltd., BioPark, Welwyn Garden City, Hertfordshire AL7 3AX, U.K.

2. Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 2 Magyar tudósok körútja, Budapest H-1117, Hungary

Funder

Nemzeti Fejleszt?si Miniszt?rium

Nemzeti Kutat?si, Fejleszt?si ?s Innov?ci?s Hivatal

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01722

Reference60 articles.

1. On the nature of allosteric transitions: A plausible model

2. A New Benzodiazepine Pharmacology