Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders-Reference-Cited by-同舟云学术

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Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

Published:2014-09 Issue:9 Volume:13 Page:692-708
ISSN:1474-1776
Container-title:Nature Reviews Drug Discovery
language:en
Short-container-title:Nat Rev Drug Discov

Author:

Conn P. Jeffrey,Lindsley Craig W.,Meiler Jens,Niswender Colleen M.

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Link

http://www.nature.com/articles/nrd4308.pdf

Reference153 articles.

1. Chalmers, D. T. & Behan, D. P. The use of constitutively active GPCRs in drug discovery and functional genomics. Nature Rev. Drug Discov. 1, 599–608 (2002).

2. Lagerström, M. C. & Schiöth, H. B. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nature Rev. Drug Discov. 7, 339–357 (2008).

3. Overington, J. P., Al-Lazikani, B. & Hopkins, A. L. How many drug targets are there? Nature Rev. Drug Discov. 5, 993–996 (2006).

4. Kola, I. & Landis, J. Can the pharmaceutical industry reduce attrition rates? Nature Rev. Drug Discov. 3, 711–715 (2004).

5. Christopoulos, A. & Kenakin, T. G protein-coupled receptor allosterism and complexing. Pharmacol. Rev. 54, 323–374 (2002).

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