Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications-Reference-Cited by-同舟云学术

Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications

Published:2017-03-01 Issue:6 Volume:60 Page:2470-2484
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Galambos János¹,Bielik Attila¹,Krasavin Mikhail²^ORCID,Orgován Zoltán³,Domány György¹,Nógrádi Katalin¹,Wágner Gábor¹,Balogh György T.¹,Béni Zoltán¹,Kóti János¹,Szakács Zoltán¹,Bobok Amrita¹,Kolok Sándor¹,Mikó-Bakk Mónika L.¹,Vastag Mónika¹,Sághy Katalin¹,Laszy Judit¹,Halász Attila Sándor¹,Balázs Ottilia¹,Gál Krisztina¹,Greiner István¹^ORCID,Szombathelyi Zsolt¹,Keserű György M.³^ORCID

Affiliation:

1. Gedeon Richter Plc, 19-21 Gyömrői út, Budapest, 1103 Hungary

2. Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Prospekt, Peterhof, 198504 Russia

3. Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 2 Magyar tudósok körútja, Budapest, 1117 Hungary

Funder

Nemzetgazdasági Minisztérium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01858

Reference35 articles.

1. Molecular Diversity of Glutamate Receptors and Implications for Brain Function

2. Mavoglurant in adolescents with fragile X syndrome: analysis of Clinical Global Impression-Improvement source data from a double-blind therapeutic study followed by an open-label, long-term extension study

3. Treatment of Anxiety Using Fenobam (a Nonbenzodiazepine) in a Double-Blind Standard (Diazepam) Placebo-Controlled Study