Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety-Reference-Cited by-同舟云学术

Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety

Published:2021-04-12 Issue:9 Volume:64 Page:5404-5428
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sainas Stefano¹^ORCID,Giorgis Marta¹^ORCID,Circosta Paola²³^ORCID,Gaidano Valentina²⁴^ORCID,Bonanni Davide¹^ORCID,Pippione Agnese C.¹^ORCID,Bagnati Renzo⁵^ORCID,Passoni Alice⁵^ORCID,Qiu Yaqi⁶⁷^ORCID,Cojocaru Carina Florina⁶^ORCID,Canepa Barbara⁸,Bona Alessandro⁹,Rolando Barbara¹^ORCID,Mishina Mariia¹^ORCID,Ramondetti Cristina¹⁰^ORCID,Buccinnà Barbara¹⁰^ORCID,Piccinini Marco¹⁰^ORCID,Houshmand Mohammad²³^ORCID,Cignetti Alessandro¹¹^ORCID,Giraudo Enrico¹⁶^ORCID,Al-Karadaghi Salam¹²^ORCID,Boschi Donatella¹^ORCID,Saglio Giuseppe²¹¹^ORCID,Lolli Marco L.¹^ORCID

Affiliation:

1. Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy

2. Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin 10043, Italy

3. Molecular Biotechnology Center, University of Turin, Via Nizza 52, Turin 10126, Italy

4. Division of Hematology, AO SS Antonio e Biagio e Cesare Arrigo, Via Venezia 16, Alessandria 15121, Italy

5. Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy

6. Laboratory of Tumor Microenvironment, Candiolo Cancer Institute, FPO, IRCCS, Candiolo, Strada Provinciale, 142-KM 3.95, Candiolo, Turin 10060, Italy

7. Higher Education Mega Center, Institutes for Life Sciences, South China University of Technology, Guangzhou 510641, China

8. Gem Forlab srl, Via Ribes, 5, Colleretto Giacosa, Turin 10010, Italy

9. Gem Chimica srl, Via Maestri del Lavoro, 25, Busca, Cuneo 12022, Italy

10. Department of Oncology, University of Turin, Via Michelangelo 27/B, Turin 10125, Italy

11. Division of Hematology and Cell Therapy, AO Ordine Mauriziano, Largo Filippo Turati, 62, Turin 10128, Italy

12. Department of Biochemistry and Structural Biology, Lund University, Naturvetarvägen 14, Box 124, Lund 221 00, Sweden

Funder

Universit? degli Studi di Torino

Associazione Italiana per la Ricerca sul Cancro

Ministero degli Affari Esteri e della Cooperazione Internazionale

Publisher

American Chemical Society (ACS)