Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors
Author:
Affiliation:
1. Janssen Pharmaceutical Research and Development, 1400 McKean Rd., Spring House, Pennsylvania 19477, United States
2. Janssen Pharmaceutical Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00543
Reference44 articles.
1. Cancer Stat Facts: Leukemia – Acute Myeloid Leukemia (AML). https://seer.cancer.gov/statfacts/html/amyl.html (accessed August 8, 2023).
2. Acute Myeloid Leukemia
3. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia
4. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
5. The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies
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