Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs-Reference-Cited by-同舟云学术

Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs

Published:2020-02-28 Issue:7 Volume:63 Page:3756-3762
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ward Jennifer A.¹²³^ORCID,Pinto-Fernandez Adan²⁴,Cornelissen Loïc⁵,Bonham Sarah²,Díaz-Sáez Laura¹²,Riant Olivier⁵^ORCID,Huber Kilian V. M.¹²^ORCID,Kessler Benedikt M.²,Feron Olivier⁴,Tate Edward W.³^ORCID

Affiliation:

1. Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, U.K.

2. Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K.

3. Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, London W12 0BZ, U.K.

4. Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, Brussels B-1200, Belgium

5. Institute of Condensed Matter and Nanosciences, MOST Division, Place Louis Pasteur, UCLouvain, Louvain-la-Neuve B-1348, Belgium

Funder

Myeloma UK

Institute of Chemical Biology EPSRC CDT (Imperial College London)

Brussels-Capital Region

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00144

Reference35 articles.