Design, Synthesis, and Structure–Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists-Reference-Cited by-同舟云学术

Design, Synthesis, and Structure–Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists

Published:2020-11-18 Issue:23 Volume:63 Page:14989-15012
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rahman Md Toufiqur¹,Decker Ann M.¹,Langston Tiffany L.¹,Mathews Kelly M.¹,Laudermilk Lucas¹,Maitra Rangan¹^ORCID,Ma Weiya²,Darcq Emmanuel²³^ORCID,Kieffer Brigitte L.²³,Jin Chunyang¹^ORCID

Affiliation:

1. Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States

2. Douglas Research Center, Department of Psychiatry, McGill University, Montréal Quebec, H4H 1R3, Canada

3. INSERM U1114, University of Strasbourg, Strasbourg 67085, France

Funder

National Institute on Alcohol Abuse and Alcoholism

National Institute of Mental Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01581

Reference39 articles.

1. A Novel G-Protein-Coupled Receptor Gene Expressed in Striatum

2. Identification of novel striatal genes by expression profiling in adult mouse brain

3. Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents

4. GPR88: A putative signaling molecule predominantly expressed in the striatum: Cellular localization and developmental regulation

5. Transcriptome analysis identifies genes with enriched expression in the mouse central extended amygdala

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