Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for <i>In Vivo</i> Mouse Studies-Reference-Cited by-同舟云学术

Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for In Vivo Mouse Studies

Published:2024-07-01 Issue:13 Volume:67 Page:11296-11325
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fer Mickael¹,Amalric Camille¹,Arban Roberto²,Baron Luc¹,Ben Hamida Sami³⁴,Breh-Schlanser Petra²,Cui Yunhai²^ORCID,Darcq Emmanuel³⁵,Eickmeier Christian²,Faye Vincent¹,Franchet Christel¹,Frauli Mélanie¹,Halter Célia¹,Heyer Marjorie¹,Hoenke Christoph²,Hoerer Stefan²,Hucke Oliver T.²^ORCID,Joseph Christophe¹,Kieffer Brigitte L.³⁵,Lebrun Louison¹,Lotz Noémie¹,Mayer Stanislas¹,Omrani Azar²,Recolet Mandy¹,Schaeffer Laurent¹,Schann Stephan¹,Schlecker Annette²,Steinberg Edith¹,Viloria Mélanie¹,Würstle Klaus²,Young Kyle²,Zinser Alexander²,Montel Florian²^ORCID,Klepp Julian²

Affiliation:

1. Domain Therapeutics, 67400 Illkirch, France

2. Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach an der Riß, Germany

3. Douglas Research Center, Department of Psychiatry, McGill University, Montréal, Quebec H4H 1R3, Canada

4. INSERM UMR 1247- Research Group on Alcohol & Pharmacodependences (GRAP), Université de Picardie Jules Verne, 80000 Amiens, France

5. INSERM UMR-S1329, Strasbourg Translational Neuroscience & Psychiatry, University of Strasbourg, Strasbourg 67084, France

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00665

Reference43 articles.

1. Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target

2. A Novel G-Protein-Coupled Receptor Gene Expressed in Striatum

3. Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist

4. Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice

5. Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research