Design, Synthesis, and Structure–Activity Relationship Studies of Novel GPR88 Agonists (4-Substituted-phenyl)acetamides Based on the Reversed Amide Scaffold-Reference-Cited by-同舟云学术

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Design, Synthesis, and Structure–Activity Relationship Studies of Novel GPR88 Agonists (4-Substituted-phenyl)acetamides Based on the Reversed Amide Scaffold

Published:2023-12-12 Issue:1 Volume:15 Page:169-192
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Rahman Md Toufiqur¹^ORCID,Guan Dongliang¹^ORCID,Chaminda Lakmal Hetti Handi¹,Decker Ann M.¹^ORCID,Imler Gregory H.²^ORCID,Kerr Andrew T.²,Harris Danni L.¹,Jin Chunyang¹^ORCID

Affiliation:

1. Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States

2. Center for Biomolecular Science and Engineering, Naval Research Laboratory, Code 6920, Washington, District of Columbia 20375, United States

Funder

National Institute on Alcohol Abuse and Alcoholism

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.3c00684

Reference48 articles.

1. A Novel G-Protein-Coupled Receptor Gene Expressed in Striatum

2. Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents

3. GPR88: A putative signaling molecule predominantly expressed in the striatum: Cellular localization and developmental regulation

4. The orphan GPCR, GPR88, modulates function of the striatal dopamine system: A possible therapeutic target for psychiatric disorders?

5. Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors

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