Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms
Author:
Affiliation:
1. Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany
2. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, D-60596 Frankfurt am Main, Germany
Funder
Aventis Foundation
LOEWE center Translational Medicine and Pharmacology, Goethe University Frankfurt am Main
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01779
Reference23 articles.
1. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors
2. NURR1 in Parkinson disease—from pathogenesis to therapeutic potential
3. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease
4. PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
5. Structure-Based Identification of OATP1B1/3 Inhibitors
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