Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism-Reference-Cited by-同舟云学术

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Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism

Published:2024-07-31 Issue:15 Volume:67 Page:13324-13348
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Willems Sabine¹^ORCID,Busch Romy¹,Nawa Felix¹,Ballarotto Marco¹²^ORCID,Lillich Felix F.³⁴,Kasch Till¹,López-García Úrsula¹,Marschner Julian A.¹,Rüger Lorena A.³,Renelt Beatrice³,Ohrndorf Julia³,Arifi Silvia³,Zaienne Daniel³,Proschak Ewgenij³⁴^ORCID,Pabel Jörg¹^ORCID,Merk Daniel¹³^ORCID

Affiliation:

1. Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany

2. Department of Pharmaceutical Sciences, Università degli Studi di Perugia, 06123 Perugia, Italy

3. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany

4. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt, Germany

Funder

European Research Council

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01218

Reference72 articles.

1. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

2. Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation

3. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Nuclear hormone receptors

4. NURR1 in Parkinson disease—from pathogenesis to therapeutic potential

5. Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 expression in both in vivo and in vitro Parkinson's disease models

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