Hitting KRAS When It’s Down
Author:
Affiliation:
1. Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 7600001, Israel
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00785
Reference6 articles.
1. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
2. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
3. The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients
4. Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer
5. Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity
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