Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization-Reference-Cited by-同舟云学术

Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization

Published:2021-01-06 Issue:2 Volume:64 Page:1103-1115
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tawada Michiko¹^ORCID,Fushimi Makoto¹,Masuda Kei¹,Sun Huikai²^ORCID,Uchiyama Noriko¹,Kosugi Yohei¹^ORCID,Lane Weston²,Tjhen Richard²,Endo Satoshi¹,Koike Tatsuki¹^ORCID

Affiliation:

1. Research, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan

2. Takeda California, Inc., 9625 Towne Centre Drive, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01712

Reference47 articles.

1. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

2. Neurodegenerative Tauopathies

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4. The Emerging Link between O-GlcNAc and Alzheimer Disease

5. O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease

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