Discovery of 4-(Arylethynyl)piperidine Derivatives as Potent Nonsaccharide O-GlcNAcase Inhibitors for the Treatment of Alzheimer’s Disease

Author:

Cheng Zihan1,Shang Nianying2,Wang Xiaoyu1,Kang Yuying2,Zhou Jie1,Lan Jiaqi2,Hu Jinping3,Peng Ying2,Xu Bailing1ORCID

Affiliation:

1. Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

2. State Key laboratory of Bioactive Substances and Functions of Natural Medicines, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

3. Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Funder

CAMS Innovation Fund for Medical Sciences

Publisher

American Chemical Society (ACS)

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