Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting-Reference-Cited by-同舟云学术

Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting

Published:2020-07-16 Issue:15 Volume:63 Page:8634-8648
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hassan Muhammad Murtaza¹²,Israelian Johan¹,Nawar Nabanita¹²,Ganda Giovanni¹²,Manaswiyoungkul Pimyupa¹²,Raouf Yasir S.¹²,Armstrong David¹^ORCID,Sedighi Abootaleb¹²^ORCID,Olaoye Olasunkanmi O.¹²,Erdogan Fettah¹²,Cabral Aaron D.¹²,Angeles Fabrizio¹²,Altintas Rabia³⁴,de Araujo Elvin D.¹,Gunning Patrick T.¹²^ORCID

Affiliation:

1. Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga ON L5L 1C6, Canada

2. Department of Chemistry, University of Toronto, 80 St. George Street, Toronto ON M5S 3H6, Canada

3. Clinical Cooperation Unit Pediatric Oncology (G340), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany

4. Heidelberg Medical Faculty, University of Heidelberg, Heidelberg 691171, Germany

Funder

Canadian Institutes of Health Research

Canada Foundation for Innovation

Ontario Research Foundation

Canada Research Chairs

Natural Sciences and Engineering Research Council of Canada

Canadian Cancer Society Research Institute