Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8-Reference-Cited by-同舟云学术

Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8

Published:2024-07-01 Issue:15 Volume:67 Page:12784-12806
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xiao Yufeng¹^ORCID,Awasthee Nikee²,Liu Yi¹,Meng Chengcheng²,He Michael Y.³,Hale Seth²,Karki Rashmi⁴,Lin Zongtao⁴,Mosterio Megan⁵,Garcia Benjamin A.⁴^ORCID,Kridel Robert³,Liao Daiqing²^ORCID,Zheng Guangrong¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States

2. Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, Florida 32610, United States

3. Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada

4. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States

5. Department of Chemistry, University of Florida, Gainesville, Florida 32610, United States

Funder

Florida Department of Health

Washington University School of Medicine in St. Louis

National Institutes of Health

National Science Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00761

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