Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3β-Reference-Cited by-同舟云学术

Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3β

Published:2021-01-27 Issue:3 Volume:64 Page:1497-1509
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Davies Matthew P.¹,Benitez Rocio²,Perez Concepción³,Jakupovic Sven⁴,Welsby Philip¹,Rzepecka Klaudia¹,Alder Jane¹,Davidson Colin¹,Martinez Ana²⁵^ORCID,Hayes Joseph M.¹^ORCID

Affiliation:

1. School of Pharmacy & Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, United Kingdom

2. Centro de Investigaciones Biologicas, CSIC, Avenida Ramiro de Maeztu 9, 28040 Madrid, Spain

3. Instituto de Quimica Medica, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain

4. AnalytiCon Discovery GmbH, Hermannswerder Haus 17, 14473 Potsdam, Germany

5. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, 28031 Madrid, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01568

Reference58 articles.

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3. GSK3 and Tau: Two Convergence Points in Alzheimer's Disease

4. Localization and Developmental Changes of τ Protein Kinase I/Glycogen Synthase Kinase-3β in Rat Brain

5. GSK-3 Inhibitors: A Ray of Hope for the Treatment of Alzheimer's Disease?

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