Discovery of Potent Multikinase Type-II Inhibitors Targeting CDK5 in the DFG-out Inactive State with Promising Potential against Glioblastoma-Reference-Cited by-同舟云学术

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Discovery of Potent Multikinase Type-II Inhibitors Targeting CDK5 in the DFG-out Inactive State with Promising Potential against Glioblastoma

Published:2024-04-30 Issue:9 Volume:67 Page:7539-7552
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Khan Zahra R.¹,Welsby Philip J.²,Stasik Izabela¹,Hayes Joseph M.¹³^ORCID

Affiliation:

1. School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, United Kingdom

2. Education Directorate, Royal College of Physicians, Liverpool L7 3FA, United Kingdom

3. Biomedical Evidence-Based Transdisciplinary (BEST) Health Research Institute, University of Central Lancashire, Preston PR1 2HE, United Kingdom

Funder

North West Cancer Research

Sydney Driscoll Neuroscience Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00373

Reference64 articles.

1. Long-term survival with glioblastoma multiforme

2. Temozolomide resistance in glioblastoma multiforme

3. The Protein Kinase Complement of the Human Genome

4. CDK5: Key Regulator of Apoptosis and Cell Survival

5. Insights into the clinical value of cyclin-dependent kinase 5 in glioma: a retrospective study

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