Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention-Reference-Cited by-同舟云学术

Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention

Published:2021-03-16 Issue:7 Volume:64 Page:3813-3826
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Whitfield Hayley¹,Hemmings Andrew M.²,Mills Stephen J.³,Baker Kendall¹,White Gaye¹,Rushworth Stuart⁴,Riley Andrew M.³^ORCID,Potter Barry V. L.³^ORCID,Brearley Charles A.¹^ORCID

Affiliation:

1. School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.

2. School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.

3. Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.

4. Department of Molecular Haematology; Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, U.K.

Funder

Wellcome Trust

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01944

Reference44 articles.

1. Analysis of Phosphatidylinositol 3,4,5 Trisphosphate 5-Phosphatase Activity by in vitro and in vivo Assays

2. Mutations in Phosphoinositide Metabolizing Enzymes and Human Disease

3. Role of SHIP in cancer

4. Targeting PI3K isoforms and SHIP in the immune system: new therapeutics for inflammation and leukemia

5. The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances inmyo-Inositol Chemistry)

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