Discovery of aurones bearing two amine functionalities as SHIP2 inhibitors with insulin-sensitizing effect in rat myotubes-Reference-Cited by-同舟云学术

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Discovery of aurones bearing two amine functionalities as SHIP2 inhibitors with insulin-sensitizing effect in rat myotubes

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Lim Phei Ching¹,Yap Beow Keat¹,Tay Yi Juin¹,Hanapi Nur Aziah²,Yusof Siti Rafidah²,Lee Chong-Yew¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia

2. Centre for Drug Research, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia

Abstract

An aurone bearing two amine functionalities 12a is a micromolar SHIP2 inhibitor with glucose uptake-enhancing property in rat myotubes. 12a showed good permeability across the Caco-2 cell monolayer indicating its potential as an oral insulin sensitizer.

Funder

Ministry of Higher Education, Malaysia

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00360D

Reference40 articles.

1. IDF Diabetes Atlas 10th Edition Committee , in IDF Diabetes Atlas , International Diabetes Federation , 10th edn, 2021 , ch. 3

2. Trends in insulin resistance: insights into mechanisms and therapeutic strategy

3. Mechanisms of Diabetic Complications

4. COVID-19 and Diabetes: Understanding the Interrelationship and Risks for a Severe Course

5. Insulin Receptor Signaling in Normal and Insulin-Resistant States

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