EFMC: Trends in Medicinal Chemistry and Chemical Biology-Reference-Cited by-同舟云学术

EFMC: Trends in Medicinal Chemistry and Chemical Biology

Published:2023-02-28 Issue:7 Volume:24 Page:
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Auberson Yves P.¹^ORCID,Arimondo Paola B.²,Duca Maria³,Essig Sebastian⁴,Grether Uwe⁵,Rufer Arne C.⁵,Sbardella Gianluca⁶,Schopfer Ulrich⁷,Torrens Antoni⁸,van der Stelt Mario⁹,Vauzeilles Boris¹⁰,Vázquez Olalla¹¹,Zhang Andrew X.¹²

Affiliation:

1. Global Discovery Chemistry Novartis Institutes for BioMedical Research Novartis Campus - WSJ-88.10 4056 Basel Switzerland

2. Department Epigenetic Chemical Biology Institut Pasteur, Université de Paris CNRS UMR3523 Chem4Life 28 rue du Dr Roux 75015 Paris France

3. Université Côte d'Azur Institut de Chimie de Nice (ICN), UMR7272 CNRS Parc Valrose 06100 Nice France

4. Bayer AG, Research & Development, Pharmaceuticals Drug Discovery Sciences, Life Science Technologies Aprather Weg 18a, Gebäude 460, Raum 345 42113 Wuppertal Germany

5. F. Hoffmann-La Roche Ltd. Pharma Research and Early Development, pRED Roche Innovation Center Basel Grenzacherstrasse 124 4070 Basel Switzerland

6. Epigenetic Med Chem Lab Department of Pharmacy, University of Salerno via Giovanni Paolo II 132 84084 Fisciano (SA) Italy

7. Chemical Biology and Therapeutics Novartis Institutes for BioMedical Research Novartis Campus – WSJ-182.Z4.249.14 4056 Basel Switzerland

8. ABAC Therapeutics S.L. Joan XXIII, 10 08950 Esplugues de Llobregat Barcelona Spain

9. University of Leiden Institute of Chemistry/Chemical Biology Gorlaeus Building, room DE3.19 Einsteinweg 55 2333 CC Leiden The Netherlands

10. Chemical Biology Department Université Paris-Saclay, CNRS Institut de Chimie des Substances Naturelles UPR 2301 91198 Gif-sur-Yvette France

11. Philipps-Universität Marburg Department of Chemistry & Center for Synthetic Microbiology (SYNMIKRO) D-35032 Marburg Germany

12. Discovery Sciences, R&D, AstraZeneca Waltham MA 02451 USA

Abstract

AbstractGround‐breaking research in disease biology and continuous efforts in method development have uncovered a range of potential new drug targets. Increasingly, the drug discovery process is informed by technologies involving chemical probes as tools. Applications for chemical probes comprise target identification and assessment, as well as the qualification of small molecules as chemical starting points and drug candidates. Progress in probe chemistry has opened the way to novel assay formats and pharmaceutical compound classes. The European Federation of Medicinal Chemistry and Chemical Biology (EFMC) has launched the Chemical Biology Initiative to advance science in the field of medicinal chemistry and chemical biology, while representing all members of this extended scientific community. This review provides an overview of the many important developments in the field of chemical biology that have happened at the lively interface of academic and industrial research.

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.202200690

Reference275 articles.

1. The Chemical Biology‐Medicinal Chemistry Continuum: EFMC′s Vision

2. Joining Forces: The Chemical Biology–Medicinal Chemistry Continuum

3. Grand Challenge Commentary: Beyond discovery: probes that see, grab and poke

4. Practical Aspects of Machine Learning for the Design-Synthesis-Purify-Assay Workflow

5. Seewww.efmc.info/chemical-biology-initiative. Since 2018 EFMC has actively pursued a strategy to reinforce the chemical biology and medicinal chemistry community in its entirety.

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