Design of Thioether Cyclic Peptide Scaffolds with Passive Permeability and Oral Exposure-Reference-Cited by-同舟云学术

Design of Thioether Cyclic Peptide Scaffolds with Passive Permeability and Oral Exposure

Published:2021-02-25 Issue:5 Volume:64 Page:2622-2633
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Golosov Andrei A.¹,Flyer Alec N.¹,Amin Jakal¹,Babu Charles¹,Gampe Christian¹,Li Jingzhou¹,Liu Eugene¹,Nakajima Katsumasa¹^ORCID,Nettleton David¹,Patel Tajesh J.¹,Reid Patrick C.²,Yang Lihua¹,Monovich Lauren G.¹^ORCID

Affiliation:

1. Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

2. PeptiDream, Inc., 3-25-23 Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa 210-0821, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01505

Reference61 articles.

1. Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges

2. Cyclic peptide therapeutics: past, present and future

3. Designing Orally Bioavailable Peptide and Peptoid Macrocycles

4. Conformational Flexibility, Internal Hydrogen Bonding, and Passive Membrane Permeability: Successful in Silico Prediction of the Relative Permeabilities of Cyclic Peptides

5. Structural and conformational determinants of macrocycle cell permeability

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