Structural and conformational determinants of macrocycle cell permeability
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nchembio.2203.pdf
Reference52 articles.
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3. Doak, B.C., Over, B., Giordanetto, F. & Kihlberg, J. Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates. Chem. Biol. 21, 1115–1142 (2014).
4. Driggers, E.M., Hale, S.P., Lee, J. & Terrett, N.K. The exploration of macrocycles for drug discovery--an underexploited structural class. Nat. Rev. Drug Discov. 7, 608–624 (2008).
5. Surade, S. & Blundell, T.L. Structural biology and drug discovery of difficult targets: the limits of ligandability. Chem. Biol. 19, 42–50 (2012).
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