Analysis of Benzenoid Substitution Patterns in Small Molecule Active Pharmaceutical Ingredients
Author:
Affiliation:
1. Department of Chemistry, Portland State University, Portland, Oregon 97201, United States
2. Process Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States
Funder
Portland State University
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00915
Reference69 articles.
1. Analysis of Benzenoid Substitution Patterns in Small Molecule Active Pharmaceutical Ingredients
2. Principal Components Describing Biological Activities and Molecular Diversity of Heterocyclic Aromatic Ring Fragments
3. The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?
4. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
5. Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery
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