Abstract
AbstractIn the past three years, bicyclo[3.1.1]heptanes and their structural analogues have emerged as useful bioisosteres of meta-substituted (hetero)arenes. To meet the increasing demand for bicyclo[3.1.1]heptanes, chemists have developed a plethora of novel methods for their synthesis. In this short review, we assess the research progress on their synthesis and functionalization, considering both the scope and mechanistic aspects. In addition, we discuss the posed challenges and the outlook for the identification of new reaction manifolds to access novel functionalized bicyclo[3.1.1]heptanes.1 Introduction2 Synthesis of Bicyclo[3.1.1]heptanes (BCHeps)3 Synthesis of 3-Azabicyclo[3.1.1]heptanes (3-Aza-BCHeps)4 Conclusion and Outlook
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Natural Science Foundation of Shaanxi Province
China Postdoctoral Science Foundation
Shaanxi Province Postdoctoral Science Foundation
Young Talent Fund of Association for Science and Technology in Shaanxi