Recent Advances in the Synthesis of Bicyclo[3.1.1]heptanes

Author:

Dong JianyangORCID,Xue Dong,Liao Huijuan

Abstract

AbstractIn the past three years, bicyclo[3.1.1]heptanes and their structural analogues have emerged as useful bioisosteres of meta-substituted (hetero)arenes. To meet the increasing demand for bicyclo[3.1.1]heptanes, chemists have developed a plethora of novel methods for their synthesis. In this short review, we assess the research progress on their synthesis and functionalization, considering both the scope and mechanistic aspects. In addition, we discuss the posed challenges and the outlook for the identification of new reaction manifolds to access novel functionalized bicyclo[3.1.1]heptanes.1 Introduction2 Synthesis of Bicyclo[3.1.1]heptanes (BCHeps)3 Synthesis of 3-Azabicyclo[3.1.1]heptanes (3-Aza-BCHeps)4 Conclusion and Outlook

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Natural Science Foundation of Shaanxi Province

China Postdoctoral Science Foundation

Shaanxi Province Postdoctoral Science Foundation

Young Talent Fund of Association for Science and Technology in Shaanxi

Publisher

Georg Thieme Verlag KG

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