Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure-Reference-Cited by-同舟云学术

Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure

Published:2021-06-03 Issue:12 Volume:64 Page:8127-8141
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Lun¹,Zheng Yunhua¹,Li Dan¹,Yang Jianhong¹,Lei Lei¹,Yan Wei¹,Zheng Wei¹,Tang Minghai¹,Shi Mingsong¹,Zhang Ruijia¹,Cai Xiaoying¹,Ni Hengfan²,Ma Xu¹,Li Na¹,Hong Feng¹,Ye Haoyu¹^ORCID,Chen Lijuan¹^ORCID

Affiliation:

1. State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu 610041, China

2. The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, People’s Republic of China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

West China Hospital, Sichuan University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01961

Reference38 articles.

1. Microtubules as a target for anticancer drugs