The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)-Reference-Cited by-同舟云学术

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)

Published:2016-01-20 Issue:3 Volume:59 Page:985-1002
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Heffron Timothy P.¹,Heald Robert A.²,Ndubaku Chudi¹,Wei BinQing¹,Augistin Martin³,Do Steven¹,Edgar Kyle¹,Eigenbrot Charles¹,Friedman Lori¹,Gancia Emanuela²,Jackson Philip S.²,Jones Graham²,Kolesnikov Aleksander¹,Lee Leslie B.¹,Lesnick John D.¹,Lewis Cristina¹,McLean Neville²,Mörtl Mario³,Nonomiya Jim¹,Pang Jodie¹,Price Steve²,Prior Wei Wei¹,Salphati Laurent¹,Sideris Steve¹,Staben Steven T.¹,Steinbacher Stefan³,Tsui Vickie¹,Wallin Jeffrey¹,Sampath Deepak¹,Olivero Alan G.¹

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Argenta, Early Discovery Charles River, 7-9 Spire Green Centre, Flex Meadow, Harlow, EssexCM19 5TR, United Kingdom

3. Proteros Biostructures GmbH, Bunsenstr. 7aD, 82152 Martinsried, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01483

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