Rational Design of a Novel 6<i>H</i>-Benzo[<i>c</i>]chromen Series as Selective PI3Kα Inhibitors-Reference-Cited by-同舟云学术

Rational Design of a Novel 6H-Benzo[c]chromen Series as Selective PI3Kα Inhibitors

Published:2024-08-19 Issue:17 Volume:67 Page:15387-15410
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shi Xue¹,Feng Heng²,Tian Haigang²,Ma Haibiao²,Pang Xiaomeng²,Mao Chenhan²,Xiang Peng²,Xu Zhengze²,Han Weidong²,Yan Yuxiang²,Chen Wei²,Nan Yuqing²,Nan Guanjun³,Hu Zhenyue¹,Hui Lingyun⁴,Li Chenglong⁵,Li Yiping²^ORCID

Affiliation:

1. Biobank, The First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, People’s Republic of China

2. Department of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, People’s Republic of China

3. Department of Pharmaceutical Analysis, School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, People’s Republic of China

4. Clinical Laboratory Center, The First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, People’s Republic of China

5. Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States

Funder

National Natural Science Foundation of China

Shaanxi Provincial Science and Technology Department

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00992

Reference45 articles.

1. The Phosphoinositide 3-Kinase Pathway

2. PI3K isoforms in cell signalling and vesicle trafficking

3. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

4. The PI3K Pathway in Human Disease

5. A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations