Hotspots in an Obligate Homodimeric Anticancer Target. Structural and Functional Effects of Interfacial Mutations in Human Thymidylate Synthase

Author:

Salo-Ahen Outi M. H.1,Tochowicz Anna2,Pozzi Cecilia3,Cardinale Daniela4,Ferrari Stefania4,Boum Yap5,Mangani Stefano3,Stroud Robert M.2,Saxena Puneet4,Myllykallio Hannu5,Costi Maria Paola4,Ponterini Glauco4,Wade Rebecca C.16

Affiliation:

1. Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, 69118 Heidelberg, Germany

2. Department of Biochemistry and Biophysics, University of California—San Francisco, San Francisco, California 94158, United States

3. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy

4. Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy

5. Ecole Polytechnique, CNRS UMR7645, INSERM U696, 91128 Palaiseau, France

6. Center for Molecular Biology, DKFZ-ZMBH Alliance, and Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, 69120 Heidelberg, Germany

Funder

National Institute of General Medical Sciences

Alexander von Humboldt-Stiftung

Itä-Suomen Yliopisto

Suomen Akatemia

Suomen Kulttuurirahasto

Sixth Framework Programme

Associazione Italiana per la Ricerca sul Cancro

Klaus Tschira Stiftung gGmbH

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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