Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia-Reference-Cited by-同舟云学术

Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia

Published:2015-12-14 Issue:24 Volume:58 Page:9625-9638
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Xixiang¹²,Wang Aoli¹³,Yu Kailin¹³,Qi Ziping¹²,Chen Cheng¹²,Wang Wenchao¹²,Hu Chen¹²,Wu Hong¹³,Wu Jiaxin¹³,Zhao Zheng¹²,Liu Juan¹²,Zou Fengming¹²,Wang Li¹²,Wang Beilei¹²,Wang Wei¹²,Zhang Shanchun²⁴,Liu Jing¹²,Liu Qingsong¹²³⁵

Affiliation:

1. High Magnetic Field Laboratory, Chinese Academy of Sciences, Mailbox 1110, 350 Shushanhu Road, Hefei 230031, Anhui, P. R. China

2. CHMFL-HCMTC Target Therapy Joint Laboratory, 350 Shushanhu Road, Hefei 230031, Anhui, P. R. China

3. University of Science and Technology of China, Hefei 230036, Anhui, P. R. China

4. Hefei Cosource Medicine Technology Co. Ltd., 358 Ganquan Road, Hefei 230031, Anhui, P. R. China

5. Hefei Science Center, Chinese Academy of Sciences, 350 Shushanhu Road, Hefei 230031, Anhui, P. R. China

Funder

Natural Science Foundation of Anhui Province

Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01611

Reference25 articles.

1. Acute Myeloid Leukemia

2. American Cancer Society.Cancer Facts & Figures 2013.American Cancer Society:Atlanta, GA, 2013.

3. FLT-3: a new focus in the understanding of acute leukemia

4. The roles of FLT3 in hematopoiesis and leukemia

5. FLT3 Tyrosine Kinase Inhibitors

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