Ibrutinib and atrial fibrillation as cardiotoxicity – A new safety warning that impacts overall survival

Author:

Parikh Purvish1,Aggarwal Indu Bansal2,Daddi Anuprita3,Narasimhan Prem Naganath4,DSouza Hollis Henry5,Agarwal Vivek6,Chandrakant M. V.7,Gopal Rakesh8

Affiliation:

1. Mumbai Oncocare Centers, Mumbai, Maharashtra, India,

2. Department of Radiation Oncology, Narayana Superspecialty Hospital, Gurgaon, Haryana, India,

3. Department of Medicine, Tata Memorial Hospital, Home Bhabha National Institute, Mumbai, Maharashtra, India,

4. Department of Geriatric Medicine, Jaslok Hospital and Research Center, Mumbai, Maharashtra, India,

5. Department of Oncology, Vedant Hospital, Mumbai, Maharashtra, India,

6. Department of Medical Oncology and Hemat-Oncology, Narayan Superspeciality Hospital & RN Tagore Hospital, Kolkata, West Bengal, India,

7. Department of Medical Oncology, Narayana Superspeciality, Kolkata, West Bengal, India,

8. Department of Cardiology, Apollo Cancer Institutes, Chennai, Tamil Nadu, India,

Abstract

Atrial fibrillation is a well recognized side effects of several drugs. However it is ignored since most studies have failed to show that it impacts survival adversely. This is not the case with ibrutinib, especially amongst patients with pre-existing cardiac morbidities. In this article, we provide practical consensus guidelines for cancer patients being commenced on therapy with ibrutinib.

Publisher

Scientific Scholar

Subject

General Medicine

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