Effect of Structural Fine-Tuning on Chelate Stability and Liver Uptake of Anionic MRI Contrast Agents-Reference-Cited by-同舟云学术

Effect of Structural Fine-Tuning on Chelate Stability and Liver Uptake of Anionic MRI Contrast Agents

Published:2022-04-14 Issue:8 Volume:65 Page:6313-6324
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Baek Ah Rum¹,Kim Hee-Kyung²,Kim Soyeon³,Yang Ji-ung³,Kang Min-Kyoung⁴,Lee Jae Jun⁴,Sung Bokyung⁵,Lee Hyeji⁶,Kim Minsup⁷,Cho Art E.⁷^ORCID,Park Ji-Ae³^ORCID,Chang Yongmin¹⁵⁶⁸⁹^ORCID

Affiliation:

1. Institute of Biomedical Engineering Research, Kyungpook National University, 41405 Daegu, Korea

2. Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation, 41061 Daegu, Korea

3. Division of RI-Convergence Research, Korea Institute of Radiological and Medical Sciences, 139-706 Seoul, Korea

4. Laboratory Animal Center, KBIO Osong Medical Innovation Foundation, 28160 Osong, Korea

5. Department of Medical & Biological Engineering, Kyungpook National University, 41944 Daegu, Korea

6. Department of Biomedical Science, Kyungpook National University, 419944 Daegu, Korea

7. InCerebro Drug Discovery Institute, 01811 Seoul, Korea

8. Department of Radiology, Kyungpook National University Hospital, 41944 Daegu, Korea

9. Department of Molecular Medicine, School of Medicine, Kyungpook National University, 41944 Daegu, Korea

Funder

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00291

Reference50 articles.

1. Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters

2. The Effect of a Phosphodiester Linking Group on Albumin Binding, Blood Half-Life, and Relaxivity of Intravascular Diethylenetriaminepentaacetato Aquo Gadolinium(III) MRI Contrast Agents

3. Impact of Hepatic Uptake Transporters on Pharmacokinetics and Drug−Drug Interactions: Use of Assays and Models for Decision Making in the Pharmaceutical Industry

4. Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers

5. Manganese-Based Contrast Agents for Magnetic Resonance Imaging of Liver Tumors: Structure–Activity Relationships and Lead Candidate Evaluation

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