Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors-Reference-Cited by-同舟云学术

Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors

Published:2022-08-03 Issue:16 Volume:65 Page:11126-11149
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Specker Edgar¹^ORCID,Matthes Susann²,Wesolowski Radoslaw²,Schütz Anja²,Grohmann Maik²,Alenina Natalia²³^ORCID,Pleimes Dirk⁴,Mallow Keven¹,Neuenschwander Martin¹,Gogolin Angelina¹⁵,Weise Marie¹⁵,Pfeifer Jochen⁵,Ziebart Nandor¹⁶,Heinemann Udo²⁶,von Kries Jens Peter¹,Nazaré Marc¹^ORCID,Bader Michael²³⁷⁸

Affiliation:

1. Chemical Biology Platform, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str.10, 13125 Berlin-Buch, Germany

2. Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC), Robert-Rössle-Str. 10, 13125 Berlin-Buch, Germany

3. German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany

4. SCINSPIRE Holding & Consulting GmbH, Dunckerstr. 25, 10437 Berlin, Germany

5. Berliner Hochschule für Technik (BHT), Luxemburger Str. 10, 13353 Berlin, Germany

6. Freie Universität Berlin, Chemistry and Biochemistry Institute, Takustr. 3, 14195 Berlin, Germany

7. University of Lübeck, Institute for Biology, Ratzeburger Allee 160, 23562 Lübeck, Germany

8. Charité−Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany

Funder

Bundesministerium f?r Bildung und Forschung

Helmholtz Association

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00598

Reference64 articles.

1. Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule

2. A unique central tryptophan hydroxylase isoform

3. Phenylalanine hydroxylase contributes to serotonin synthesis in mice

4. Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform

5. Tryptophan Hydroxylase as Novel Target for the Treatment of Depressive Disorders

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