Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors-Reference-Cited by-同舟云学术

Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors

Published:2023-10-31 Issue:21 Volume:66 Page:14866-14896
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Specker Edgar¹²^ORCID,Wesolowski Radoslaw²³,Schütz Anja³,Matthes Susann³,Mallow Keven¹,Wasinska-Kalwa Malgorzata¹,Winkler Lars⁴^ORCID,Oder Andreas¹,Alenina Natalia³⁵^ORCID,Pleimes Dirk²,von Kries Jens Peter¹,Heinemann Udo³,Bader Michael²³⁵⁶⁷,Nazaré Marc¹^ORCID

Affiliation:

1. Chemical Biology Platform, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany

2. Trypto Therapeutics GmbH, Robert-Rössle Straße 10, 13125 Berlin, Germany

3. Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany

4. Experimental Pharmacology and Oncology GmbH, Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany

5. German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Potsdamer Straße 58, 10785 Berlin, Germany

6. Charité─Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany

7. University of Lübeck, Institute for Biology, Ratzeburger Allee 160, 23562 Lübeck, Germany

Funder

Bundesministerium für Bildung und Forschung

Bundesministerium für Wirtschaft und Klimaschutz

Helmholtz-Gemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01454

Reference42 articles.

1. Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform

2. A unique central tryptophan hydroxylase isoform

3. Effect of Tryptophan Hydroxylase 1 Deficiency on the Development of Hypoxia-Induced Pulmonary Hypertension

4. The serotonin hypothesis in pulmonary hypertension revisited: targets for novel therapies (2017 Grover Conference Series)

5. Production of Serotonin by Tryptophan Hydroxylase 1 and Release via Platelets Contribute to Allergic Airway Inflammation

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