Synthesis and Pharmacological Evaluation of New <i>N</i>-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout-Reference-Cited by-同舟云学术

Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout

Published:2022-04-11 Issue:8 Volume:65 Page:6250-6260
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Narros-Fernández Paloma¹²³,Chioua Mourad⁴,Petcu Sonia A.⁴,Diez-Iriepa Daniel⁴⁵,Cerrada-Gálvez Laura¹²³,Decouty-Pérez Céline¹²³,Palomino-Antolín Alejandra¹²³,Ramos Eva⁶^ORCID,Farré-Alins Víctor¹²³,López-Rodríguez Ana Belén¹²³,Romero Alejandro⁶^ORCID,Marco-Contelles José⁴,Egea Javier¹²³^ORCID

Affiliation:

1. Molecular Neuroinflammation and Neuronal Plasticity Research Laboratory, Hospital Universitario Santa Cristina, Calle Maestro Vives 2, 28009 Madrid, Spain

2. IIS-Hospital Universitario de La Princesa, 28006 Madrid, Spain

3. Departamento de Farmacología y Terapéutica, Facultad de Medicina, Instituto Teófilo Hernando, UAM, Madrid 28029, Spain

4. Laboratory of Medicinal Chemistry (IQOG, CSIC), Juan de La Cierva 3, Madrid 28006, Spain

5. Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá, Ctra. Madrid-Barcelona km 33.6, Alcalá de Henares 28871, Spain

6. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Complutense University of Madrid, Madrid 28040, Spain

Funder

Fundación Mutua Madrileña

Ministerio de Ciencia e Innovación

European Regional Development Fund

Instituto de Salud Carlos III

Publisher

American Chemical Society (ACS)