Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity-Reference-Cited by-同舟云学术

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Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity

Published:2024-05-16 Issue:11 Volume:67 Page:9406-9430
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

He Chen¹,Liu Junkai¹,Li Junda¹,Wu Hongyu¹,Jiao Chenyang²,Ze Xiaotong¹,Xu Shengtao¹,Zhu Zheying³,Guo Wenjie²,Xu Jinyi¹^ORCID,Yao Hong¹^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, P. R. China

2. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, P. R. China

3. Division of Molecular Therapeutics & Formulation, School of Pharmacy, The University of Nottingham, Nottingham NG7 2RD, U.K.

Funder

Natural Science Foundation of Jiangsu Province

Double First Class University Plan

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00504

Reference79 articles.

1. Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases

2. Inflammasomes contributing to inflammation in arthritis

3. Crosstalk between ER stress, NLRP3 inflammasome, and inflammation

4. Inflammasomes: mechanism of action, role in disease, and therapeutics

5. Cryo-EM structures of the active NLRP3 inflammasome disc

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