Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα-Reference-Cited by-同舟云学术

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα

Published:2022-12-01 Issue:24 Volume:65 Page:16589-16621
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hanan Emily J.¹^ORCID,Braun Marie-Gabrielle¹^ORCID,Heald Robert A.²^ORCID,MacLeod Calum²,Chan Connie¹,Clausen Saundra¹,Edgar Kyle A.¹,Eigenbrot Charles¹,Elliott Richard²,Endres Nicholas¹,Friedman Lori S.¹^ORCID,Gogol Emily¹,Gu Xiao-Hui³,Thibodeau Rebecca Hong¹,Jackson Philip S.²,Kiefer James R.¹,Knight Jamie D.²,Nannini Michelle¹,Narukulla Raman²,Pace Amanda¹,Pang Jodie¹,Purkey Hans E.¹^ORCID,Salphati Laurent¹,Sampath Deepak¹,Schmidt Stephen¹,Sideris Steve¹,Song Kyung¹,Sujatha-Bhaskar Swathi¹,Ultsch Mark¹,Wallweber Heidi¹,Xin Jianfeng³,Yeap SiewKuen²,Young Amy¹,Zhong Yu¹,Staben Steven T.¹^ORCID

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K.

3. Pharmaron Beijing Co., Ltd, No. 6 Taihe Road, BDA, Beijing 100176, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01422

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5. Discovery and saturation analysis of cancer genes across 21 tumour types

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