Linker-Dependent Folding Rationalizes PROTAC Cell Permeability-Reference-Cited by-同舟云学术

Linker-Dependent Folding Rationalizes PROTAC Cell Permeability

Published:2022-09-28 Issue:19 Volume:65 Page:13029-13040
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Poongavanam Vasanthanathan¹^ORCID,Atilaw Yoseph¹,Siegel Stephan²,Giese Anja²,Lehmann Lutz³,Meibom Daniel³^ORCID,Erdelyi Mate¹^ORCID,Kihlberg Jan¹^ORCID

Affiliation:

1. Department of Chemistry─BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden

2. Drug Discovery Sciences, Bayer AG, 13342 Berlin, Germany

3. Drug Discovery Sciences, Bayer AG, 42113 Wuppertal, Germany

Funder

Vetenskapsr?det

Bayer

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00877

Reference62 articles.

1. PROTAC targeted protein degraders: the past is prologue

2. PROTAC-DB: an online database of PROTACs

3. Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’ chemical space: Recent progress and future challenges

4. Developing degraders: principles and perspectives on design and chemical space

5. PROTAC cell permeability and oral bioavailability: a journey into uncharted territory

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