PROTAC cell permeability and oral bioavailability: a journey into uncharted territory
Author:
Affiliation:
1. Department of Chemistry - BMC, Uppsala University, SE-75123, Uppsala, Sweden
Funder
Vetenskapsrådet
Bayer
Publisher
Future Science Ltd
Subject
Drug Discovery,Pharmacology,Molecular Medicine
Link
https://www.future-science.com/doi/pdf/10.4155/fmc-2021-0208
Reference20 articles.
1. Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’ chemical space: Recent progress and future challenges
2. Developing degraders: principles and perspectives on design and chemical space
3. Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
4. Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection
5. DrugBank 5.0: a major update to the DrugBank database for 2018
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