Radioactive ADME Demonstrates ARV-110’s High Druggability Despite Low Oral Bioavailability-Reference-Cited by-同舟云学术

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Radioactive ADME Demonstrates ARV-110’s High Druggability Despite Low Oral Bioavailability

Published:2024-07-29 Issue:16 Volume:67 Page:14277-14291
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

He Yifei¹²,Zheng Yuandong¹,Zhu Chenggu³,Lei Peng¹,Yu Jinghua¹,Tang Chongzhuang⁴,Chen Hao¹²^ORCID,Diao Xingxing¹²⁴^ORCID

Affiliation:

1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

2. University of the Chinese Academy of Sciences, Beijing 100049, China

3. Wuxi Beita Pharmatech Co., Ltd., Wuxi 214437, China

4. XenoFinder Co., Ltd., Suzhou 215123, China

Funder

Guangdong Provincial Department of Science and Technology

National Key Research and Development Program of China

National Natural Science Foundation of China

Wuxi Beita Pharmatech Co., Ltd.

XenoFinder Co., Ltd.

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01104

Reference40 articles.

1. Waste disposal—An attractive strategy for cancer therapy

2. Targeted protein degradation: A promise for undruggable proteins

3. PROTACs: past, present and future

4. Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

5. Induced protein degradation: an emerging drug discovery paradigm

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