Developing degraders: principles and perspectives on design and chemical space-Reference-Cited by-同舟云学术

Developing degraders: principles and perspectives on design and chemical space

Published:2019 Issue:10 Volume:10 Page:1755-1764
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Maple Hannah J.¹²³⁴^ORCID,Clayden Nat¹²³⁴,Baron Anne¹²³⁴,Stacey Callum¹²³⁴,Felix Robert¹²³⁴^ORCID

Affiliation:

1. Bio-Techne (Tocris)

2. The Watkins Building

3. Bristol

4. UK

Abstract

Degraders (e.g. PROTACs, SNIPERs, degronimers etc.) are a new modality offering increasing potential both as tools for basic research and therapeutic development.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00272C

Reference48 articles.

1. Catalytic in vivo protein knockdown by small-molecule PROTACs

2. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

3. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

4. Lead- and drug-like compounds: the rule-of-five revolution

5. ARV-110: An oral androgen receptor PROTAC degrader for prostate cancer.

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