Discovery of a Series of 5-Amide-1<i>H</i>-pyrazole-3-carboxyl Derivatives as Potent P2Y<sub>14</sub>R Antagonists with Anti-Inflammatory Characters-Reference-Cited by-同舟云学术

Discovery of a Series of 5-Amide-1H-pyrazole-3-carboxyl Derivatives as Potent P2Y₁₄R Antagonists with Anti-Inflammatory Characters

Published:2022-11-17 Issue:23 Volume:65 Page:15967-15990
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Yu-hang¹²,Zhou Meng-ze¹³,Ye Tao¹⁴,Wang Ping-ping¹²,Lu Ran¹²,Wang Yi-lin¹³,Liu Chun-xiao¹³,Xiao Wen¹²,Li Jia-yi¹²,Meng Zi-bo¹²,Xu Li-li¹²⁴^ORCID,Hu Qing-hua¹³^ORCID,Jiang Cheng¹²

Affiliation:

1. School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, P. R. China

2. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, P. R. China

3. State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, P. R. China

4. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, P. R. China

Funder

Central University Basic Research Fund of China

Government of Jiangsu Province

National Natural Science Foundation of China

Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01632

Reference45 articles.

1. Drug-like Antagonists of P2Y Receptors—From Lead Identification to Drug Development

2. International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy

3. Purinergic regulation of the immune system

4. Purine and pyrimidine receptors

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