Discovery of Novel Imidazo[4,5-c]quinoline Derivatives to Treat Inflammatory Bowel Disease (IBD) by Inhibiting Multiple Proinflammatory Signaling Pathways and Restoring Intestinal Homeostasis

Author:

Liang Xuewu12ORCID,Xie Yongle12,Liu Xuyi12,Xu Hui12,Ren Hairu3,Tang Shuai12,Liu Qi12,Huang Min12,Shao Xueqing12,Li Chunpu12,Zhou Yu12ORCID,Geng Meiyu12,Xie Zuoquan12,Liu Hong123ORCID

Affiliation:

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai201203, China

2. University of Chinese Academy of Sciences, Beijing100049, China

3. School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou310024, China

Funder

Shanghai Municipal Health and Family Planning Commission

National Natural Science Foundation of China

Lingang Laboratory

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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