Discovery of Novel 2-Aminopyridine-Based and 2-Aminopyrimidine-Based Derivatives as Potent CDK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors and Hematological Malignancies-Reference-Cited by-同舟云学术

Discovery of Novel 2-Aminopyridine-Based and 2-Aminopyrimidine-Based Derivatives as Potent CDK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors and Hematological Malignancies

Published:2024-08-23 Issue:17 Volume:67 Page:15220-15245
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Saidahmatov Abdusaid¹²,Li Jianan³,Xu Shihao¹²,Hu Xiaobei¹⁴,Gao Xiangqian³,Kan Weijuan¹,Gao Lixin¹,Li Cong¹,Shi Yuqiang¹,Sheng Li¹,Wang Peipei¹,Zhou Yubo¹²⁴,Liang Xuewu¹²^ORCID,Li Jia¹²³⁴⁵,Liu Hong¹²^ORCID

Affiliation:

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China

2. University of Chinese Academy of Sciences, Beijing 100049, China

3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China

4. Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan Tsuihang New District, Guangdong 528400, China

5. State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China

Funder

National Natural Science Foundation of China

Alliance of International Science Organizations

Lingang Laboratory

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00837

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