Fragment-Based Anti-inflammatory Agent Design and Target Identification: Discovery of AF-45 as an IRAK4 Inhibitor to Treat Ulcerative Colitis and Acute Lung Injury-Reference-Cited by-同舟云学术

Fragment-Based Anti-inflammatory Agent Design and Target Identification: Discovery of AF-45 as an IRAK4 Inhibitor to Treat Ulcerative Colitis and Acute Lung Injury

Published:2024-06-24 Issue:13 Volume:67 Page:10687-10709
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zou Yu¹²,Wang Xiemin¹²,Chen Pan¹²³,Zheng Zhiwei¹²⁴^ORCID,Li Xiaobo¹²,Chen Zhichao¹²,Guo Mi¹²,Zhou Ying¹²,Sun Chenhui¹²,Wang Ran⁵,Zhu Wufu⁵^ORCID,Zheng Pengwu⁵,Cho Won-Jea⁴,Cho Young-Chang⁴,Liang Guang¹⁶²³^ORCID,Tang Qidong¹²

Affiliation:

1. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China

2. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China

3. Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China

4. College of Pharmacy, Chonnam National University, Gwangju 61186, Korea

5. Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China

6. School of Pharmacy, Hangzhou Medical College, Hangzhou 311399, China

Funder

Wenzhou Medical University

Major Scientific and Technological Project of Zhejiang Province

Wenzhou Institute of Biomaterials and Engineering

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00202

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